Predicted aerosol dosimetry for mouse models of chronic obstructive pulmonary disease, cardiovascular disease and lung cancer

Introduction For in vivo inhalation studies, aerosol dosimetry links exposure and deposited dose within the respiratory tract. Aerosol programs like Multiple Path Particle Deposition model utilize tract geometry, physiology, properties to predict particle deposition A challenge wider use of these for studies is lack species-specific or strain specific anatomy, some cases, physiology data. The objective this work was develop predictions human disease models chronic obstructive pulmonary (COPD; C57BL/6 mice) cardiovascular (CVD; ApoE-/- mice), lung cancer (AJ using model. Methods Microcomputed tomography derived tracheobronchial geometry data were combined with available C57BL/6, ApoE-/-, AJ mice incorporated into Mouse literature values used as input Results resulting compared well very limited experimental Since multiple geometries thus anatomies mice, an estimate intrastrain variability predicted obtained. Discussion Conclusions always smaller airways. differences reported resulted greater than observed different anatomies. These mouse can provide insight delivered regions that be correlated endpoints.